Study: Combination Therapy Reduces PONV After Bariatric Surgery
Zofran and aprepitant slashed incidence to 3%.
Published: October 15, 2013
Bariatric surgery patients who are given a combination of Zofran and aprepitant experience a dramatically reduced incidence of PONV, according to a study presented at the ongoing Anesthesiology 2013 annual meeting in San Francisco and reported by Science Daily.
In a study of 124 patients, 64 were given both Zofran and aprepitant within 1 hour of the anticipated start of anesthesia; 60 were given only Zofran and a placebo. Only 3% of the combination group experienced PONV, compared with 15% of the placebo group.
The study was presented by Ashish Sinha, MD, PhD, vice chair of anesthesiology and perioperative medicine at Drexel University College of Medicine, Philadelphia. Dr. Sinha will also be a featured speaker at Outpatient Surgery Magazine's ORExcellence in Las Vegas, next week.
"The consequences of vomiting can be very serious (after weight-loss surgery because) the stomach is transformed to a small, one-ounce sac," says Dr. Sinha. "Vomiting risks rupturing the fresh incision as the contents of the stomach try to violently exit the narrow, freshly created stomach pouch. There are multiple receptors in the brain stem that trigger vomiting; if we use the combination therapy, we can increase the number of receptors blocked and lower the incidence of vomiting."
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