Cataract surgery patients are traditionally prescribed a regimen of antibiotic eyedrops to ward off the risk of post-op infection. But ophthalmic surgeons at Kaiser Permanente in northern California have determined that injecting antibiotics at the close of surgery is a much more effective method.
For the study, published online in the Journal of Cataract and Refractive Surgery, the researchers calculated the incidence rate of endopthalmitis following more than 16,000 cataract cases performed between 2007 and 2011.
During the baseline year of 2007, cataract patients were administered post-op eyedrops only. The endopthalmitis rate was 3.1 per 1,000 cases. "Antibiotic eyedrops applied to the surface of the eye must penetrate inside the eye to reach the site where pathogens can take hold and cause infection," notes Neal Shorstein, MD, the study's lead author.
Administering antibiotics directly into the anterior chamber boosted the effect, however, as seen in 2008's and 2009's cases, in which an injection of cefuroxime was added to the eyedrop regimen. In those cases, the endopthalmitis rate was 1.43 per 1,000 cases.
What's more, in 2010 and 2011, when every cataract patient received an injection of cefuroxime, moxifloxacin or vancomycin, the rate dropped to 0.14 per 1,000 cases, a rate 22 times lower than in 2007.
David Bernard
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