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What's the difference between ephedrine and epinephrine? Their names may look alike and sound alike, but these 2 drugs are hardly interchangeable. Epinephrine is a better vasoconstrictor than ephedrine but less of a stimulator to the central nervous system. Ephedrine, meanwhile, has a longer duration but a slower onset. Because ephedrine/epinephrine and other confusing look-alike/sound-alike drug pairs have similar names and may be stored in close proximity to one another, they can lead to potentially harmful medication errors if you don't take proper precautions to prevent them.
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