The skin is the first and most effective line of defense against infection. When that line is breached - whether it's the purposeful cutting of a patient for surgery, or the unwittingly cracked, dry skin of the surgical staff - microorganisms have a chance to enter the body. Personal protective equipment and surgical drapes shield your clinical team from bloodborne pathogens, but also serve as important barriers against the transfer of potentially harmful microbes to the patient. The use of barrier protection is standard practice, but here are some evidence-based tips and facts that will reinforce the importance of ensuring the safety of your patients.