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This may surprise you, but science has never proven for certain that antiseptic prepping of a surgical site actually reduces the risk of SSI. Unfortunately, there is more we don't know about prepping as an SSI-reducing measure than what infection control experts know for certain. This is what we do know. We know that human skin harbors a multitude of microorganisms. We know that SSI risk increases markedly with a bacterial concentration of more than one million microbes per gram of tissue. Therefore, most experts believe it makes sense to pre-emptively reduce the bacterial population adjacent to the surgical site incision. Here is a 6-question quiz to test your knowledge on recommended prepping practices. The answers may not be as clear-cut as they seem at first glance.